Sudden cardiac death of a 16-year-old boy with Wolff-Parkinson-White syndrome and hypertrophic cardiomyopathy

Mitochondrial hypertrophic cardiomyopathy associated with Wolff-Parkinson-White syndrome.

490 aspartate aminotransferase 147 U/L (normal <37). Due to abnormal serum lactate determination (3.8 μmol/L, normal <2.0), a skeletal muscle biopsy was processed to search for enzymatic activity in the respiratory-chain complex. The patient was transferred to our cardiology hospital at 71 days of age, with tachycardia of 300 beats/min, blood pressure of 90/60 mmHg, mild cyanosis and diaphoresi...

Wolff-Parkinson-White Syndrome: A Stepwise Deterioration to Sudden Death.

[Sudden death in the Wolff-Parkinson-White syndrome].

Clinical electrophysiologic studies in patients with Wolff-Parkinson-White syndrome (WPW) suffering from ventricular fibrillation have shown a high prevalence of short anterograde refractory period of the accessory pathway (less than or equal to 250 ms), short preexcited RR intervals during atrial fibrillation (less than or equal to 250 ms), and multiple accessory pathways. Unfortunately the sp...

Apical Hypertrophic Cardiomyopathy in a Case with Chest Pain and Family History of Sudden Cardiac Death: A Case Report

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease, which is caused by a multitude of mutations in genes encoding proteins of the cardiac sarcomere (1). Apical hypertrophic cardiomyopathy (AHCM) is an uncommon type of HCM. The sudden cardiac death is less likely to occur in the patients inflicted with AHCM (2). Herein, we presented the case of a 29-year-old man ...

Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3.

We have mapped a disease locus for Wolff-Parkinson-White syndrome (WPW) and familial hypertrophic cardiomyopathy (FHC) segregating in a large kindred to chromosome 7 band q3. Although WPW syndrome and FHC have been observed in members of the same family in prior studies, the relationship between these two diseases has remained enigmatic. A large family with 25 surviving individuals who are affe...